Comparative efficacy of topical Adipocyte-derived Mesenchymal Stem Cells-Conditioned Medium (ADMSC-CM) and Amniotic Membrane Mesenchymal Stem Cells-Conditioned Medium (AMSC-CM) on chronic plantar ulcers in leprosy: a randomized controlled trial

Introduction: Chronic Plantar Ulcer of Leprosy (CPUL), one the debilitating disabilities and complications, poses a treatment challenge. Utilization stem cells, specifically adipocyte-derived mesenchymal cells-conditioned medium (ADMSC-CM) amniotic membrane (AMSC-CM), may serve as novel therapeutic option. This study aims to compare efficacy topical ADMSC-CM, AMSC-CM, farmazertin gauze dressing (FGD) only on healing CPUL.Methods: In this randomized controlled trial, our recruited 54 subjects with CPUL. Subjects were randomly assigned ADMSC-CM (n = 16), AMSC-CM 22), or FGD 16) applied every three days for up 8 weeks. Data analyzed using SPSS version 20 Windows.Results: Healing percentage increased each week in all groups. Statistic differences between groups (p <0.05) observed ulcer mean size depth reduction from onwards. No adverse reactions complications reported. At end study, based clinically improved ulcers, (100.0%) superior improving CPULs compared (54.55%) (50.0%).Conclusion: are potential agents management CPUL, being overall improvement.